Phenyl P-FRs in vitro tested for endocrine disruption. Seven phenyl phosphate PIN FRs * were tested in vitro on cultured mouse MA-10 Leydig tumour cells for effects on cellular activity, cytotoxicity and different steroid hormone productions. All 7 phenyl phosphates, and also the brominated FR (tetra-BDE = BDE-47) reduced cell mitochondrial activity and cell number (cytotoxicity).
All the phenyl phosphates but not BDE-47 increased superoxide production (oxidative cell stress). Different phenyl phosphates but not BDE-47 impacted different steroid production routes and/or progesterone biosynthesis gene expression. The authors conclude that these phenyl phosphate FRs have greater endocrine disrupter effects in this in vitro test than BDE-47.
* The phenyl phosphate FRs tested were: 2-ethylhexyl diphenyl phosphate (EDHP), isodecyl diphenyl phosphate (IDDP), triphenyl phosphate (TPHP), t-butylphenyl diphenyl phosphate (BPDP), isopropylated triphenyl phosphate (IPPP), tricresyl phosphate (TMPP) and tri-o-cresyl phosphate (TOCP). “Organophosphate Flame Retardants Act as Endocrine-Disrupting Chemicals in MA-10 Mouse Tumor Leydig Cells”, G. Schang et al., Toxicological Sciences, 2016, Apr;150(2):499-509 http://dx.doi.org/10.1093/toxsci/kfw012American Chemical Council (ACC) calls to ratify Stockholm Convention. The US chemistry industry federation, ACC, has called on the Senate to ratify the Stockholm Convention on Persistent Organic Pollutants (POPs) in order to be able to participate in discussions on future Convention decisions, such as adding new chemicals to the POPs list. The Convention is already ratified by some 180 countries. Chemicals currently proposed for addition to the POPs list include the halogenated FRs Deca-BDE and short chain chlorinated paraffins (SCCPs) and PFOA (pentadecafluorooctanoic acid) used in fire fighting foams.
“Restricting POPs: Why the Stockholm Convention matters”, American Chemistry Council 13/10/2016 https://blog.americanchemistry.com/2016/10/restricting-pops-why-the-stockholm-convention-matters/