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Posted on 15/01/2021
Long term diabetes effect of penta-BDE in mice.

Long term diabetes effect of penta-BDE in mice. Mice exposed to DE-71 (mainly penta-BDE) only via their mothers (in the womb and during lactation) showed markers of diabetes later as adults. The mothers were given PBDEs at 0.1 or 0.4 mg per day / kg body weight (considered comparable to human environmental exposure). Media coverage refers to PBDEs but the substance tested, penta-BDE, was banned worldwide by the Stockholm Convention in 2009

“Maternal transfer of environmentally relevant polybrominated diphenyl ethers (PBDEs) produces a diabetic phenotype and disrupts glucoregulatory hormones and hepatic endocannabinoids in adult mouse female offspring”, E. Kozlova et al., Nature Scientific Reports 2020 10:18102 https://doi.org/10.1038/s41598-020-74853-9

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