Penta-BDE was fed to mother mice at 0.4 mg/kg body weight per day (orders of magnitude higher than general human population exposure). PBDEs were transferred to offspring both in utero and in lactation and resulted in modifications in brain chemistry and in behaviour of offspring, including modifying social recognition and object memory, but not impacting anxiety or depressive behaviour. Media coverage suggests that such changes are comparable to symptoms of ASD (autism spectrum disorder).
“Persistent autism‑relevant behavioral phenotype and social neuropeptide alterations in female mice offspring induced by maternal transfer of PBDE congeners in the commercial mixture DE‑71”, E. Kozlova et al., Archives of Toxicology, 2021 https://doi.org/10.1007/s00204-021-03163-4
“Study shows flame retardants cause brain changes in mice offspring”, California News Times, 5th November 2021 https://californianewstimes.com/study-shows-flame-retardants-cause-brain-changes-in-mice-offspring/582884/