AlPi not skin sensitiser, not genotoxic
Tests of the PIN flame retardant AlPi conclude that it is not tested for human skin irritation and sensitisation using human keratinocyte cells, chemical modelling and biomarker analysis. AlPi at 30 – 120 mg/l did not significantly increase cell reactive oxygen (ROS, H2DCFDA) nor pro-inflammatory markers (IL-6, IL-8, IL-10, IL-1β, IL12p70, TNF). AlPi was tested for human genotoxicity by analysis of γ-H2AX, which did not significantly increase. An increase in DNA methylation markers 5-hydroxymethylcytosine (5-hmC) and TET1 was however noted, indicating the need for further research. AlPi (aluminium diethylphosphinate) was acquired from pinfa member Clariant, but Clariant and industry did not support this study.
“Evaluating dermal toxicity of the flame retardant aluminum diethylphosphinate by in silico-in vitro testing strategy”, E. Moreira Silva et al., Chemosphere 379 (2025) 144421 https://doi.org/10.1016/j.chemosphere.2025.144421
