PIN FR AlPi shows no gene or cytotoxicity

Independent study on aluminium diethyl phosphinate (AlPi, phosphorus PIN FR) concludes no cytotoxicity, not mutagenic. This study tested AlPi produced by Clariant (pinfa member). Mutagenicity was tested using the OECD 471 bacteria test (Ames test) with Salmonella. Cytotoxicity was tested for mitochondrial dehydrogenase activity (WST-1 test), for lactate dehydrogenase activity (LDH), and for in vitro cytokinesis -block micronucleus assay (invCBMN, OECD 487). Conclusions are that AlPi is neither mutagenic nor cytotoxic under the conditions tested but did show some genotoxicity (micronucleus induction, HepG2 cells) at the highest concentration tested (200 µg/ml = 0.2 g/l). Previous publications have found AlPi to be not toxic to PC12 and B35 cells (rat pheochromocytoma and neuroblastoma) (Hendriks et al. 2014) and to have low to moderate aquatic toxicity, developmental or reproductive toxicity (see references in paper).

Diagram: Wikipedia.

This study was funded by the State of Rio de Janeiro (Chagas Filho Foundation) with no industry funding.

“Genotoxicity analysis of a flame retardant, aluminum diethylphosphinate”, T. Leoncio et al., Mutation Research – Genetic Toxicology and Environmental Mutagenesis 900 (2024) 503829, https://doi.org/10.1016/j.mrgentox.2024.503829